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Detection of adrenomedullin and endothelin in the plasma of patients with systemic scleroderma
Author(s): 
Pages: 580-581
Year: Issue:  9
Journal: JOURNAL OF CLINICAL DERMATOLOGY

Keyword:  硬皮病系统性肾上腺髓质素内皮素;
Abstract: 目的:探讨肾上腺髓质素(ADM)和内皮素(ET)在系统性硬皮病(SSc)发病中的作用.方法:采用放免法测定28例SSc患者和20名健康人的血浆ADM和ET-1水平.结果:SSc患者血浆ADM水平为(222.26±48.64)pg/mL,高于正常对照组(89.07±13.00)pg/mL,两组间比较,差异有显著性(P<0.01);SSc伴肺动脉高压者其血浆中ADM水平(254.73±39.36)pg/mL明显高于不伴肺动脉高压者(206.88±45.64)pg/mL,二者之间差异有显著性(P<0.01).SSc患者血浆ET-1水平为(196.45±65.20)pg/mL,高于正常对照组(54.17±11.70)pg/mL,两组间比较,差异有显著性(P<0.01);SSc伴肺动脉高压者其血浆中ET-1水平(273.19±48.97)pg/mL明显高于不伴肺动脉高压者(160.11±31.17)pg/mL,二者之间差异有显著性(P<0.01).血浆中ADM和ET-1水平呈正相关(r=0.5148,P<0.01).结论:ADM和ET与SSc关系密切,可能在SSc发病和防治中具有重要的生理及病理学意义.
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