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The mRNA expression of Toll-like receptor-2 and 4 in the oral mucous membrane of oropharyngeal candidiasis model mice
Author(s): 
Pages: 359-361
Year: Issue:  6
Journal: JOURNAL OF CLINICAL DERMATOLOGY

Keyword:  感染口腔黏膜白念珠菌Toll样受体基因表达;
Abstract: 目的:研究小鼠口腔黏膜白念珠菌感染后局部组织Toll样受体(TLR)2、4 mRNA表达的变化规律,探讨其在口腔黏膜抗白念珠菌感染早期免疫中的作用.方法:采用局部接种的方法建立小鼠口腔黏膜白念珠菌感染模型.在不同时间取口腔组织,用半定量逆转录(RT)-PCR检测口腔组织TLR2、TLR4 mRNA表达水平.结果:接种前口腔组织内有微量的TLR2、TLR4mRNA表达,接种后6 h组织中TLR2、TLR4 mRNA表达开始增加,12~24 h表达水平达峰值.TLR4 mRNA表达于24~48 h开始下降,72 h趋于接种前水平,而TLR2 mRNA表达则持续增加至72 h.结论:白念珠菌感染可迅速上调局部组织TLR2、TLR4的基因表达,TLR2、TLR4在口腔黏膜抗白念珠菌感染早期免疫中可能起重要作用.
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