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The significance of combined assays of anti-Saccharomyces cerevisia antibody and perinuclear antineutrophil cytoplasmic antibody on differentiatial diagnosis of inflammatory bowel disease
Author(s): 
Pages: 745-747
Year: Issue:  12
Journal: CHINESE JOURNAL OF DIGESTION

Keyword:  克罗恩病溃疡性结肠炎抗酿酒酵母菌抗体核周型抗中性粒细胞胞浆抗体;
Abstract: 目的联合测定血清抗酿酒酵母菌抗体(ASCA)-IgG、ASCA-IgA和核周型抗中性粒细胞胞浆抗体(pANCA)水平,探索其对克罗恩病(CD)和溃疡性结肠炎(UC)的诊断和鉴别诊断意义.方法分别应用标准化ELISA法和间接免疫荧光法对19例炎症性肠病(IBD,UC10例,CD9例)患者和18名健康对照者血清ASCA-IgG、ASCA-IgA和pANCA水平进行测定.结果9例CD患者(末段回肠和结肠均累及)血清ASCA-IgG和ASCA-IgA水平(酶单位)分别为18.51±6.38和11.74±5.46,显著高于10例UC患者(6.98±5.24和3.88±3.52)和18名健康对照者(5.90±4.12和4.62±3.21,P值均<0.05),pANCA诊断UC的敏感性为80%,而CD患者和健康对照者的阳性检测率均为0%.结论ASCA是一种对CD具有特异性的抗体,pANCA是与UC显著正相关的一个免疫学指标.它们均有助于CD与UC的诊断和鉴别诊断,是IBD非创伤性鉴别诊断方法之一.
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