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The study on the influence of different dose of corticosteroid in the treatment of SLE
Author(s): 
Pages: 410-412
Year: Issue:  7
Journal: JOURNAL OF CLINICAL DERMATOLOGY

Keyword:  红斑狼疮系统性糖皮质激素冲击治疗常规治疗;
Abstract: 目的:探讨小剂量糖皮质激素冲击和常规剂量糖皮质激素治疗系统性红斑狼疮(SLE)的疗效及适应证.方法:用小剂量糖皮质激素冲击治疗103例SLE患者,常规剂量糖皮质激素治疗98例SLE患者.3周后观察两组患者临床症状缓解时间、各项实验室检查指标的好转率及不良反应.结果:两组患者部分临床症状缓解时间、实验室检查指标的好转率及不良反应发生率经统计学分析差异有显著性(P<0.05).结论:小剂量糖皮质激素冲击治疗SLE患者的关节疼痛、发热、蛋白尿的疗效优于常规剂量治疗,而常规剂量糖皮质激素治疗甲周红斑、口腔溃疡、抗ds-DNA抗体阳性、抗核抗体(ANA)阳性、低血红蛋白的疗效优于小剂量糖皮质激素冲击治疗.两种方法治疗蝶形红斑和血小板、白细胞、红细胞减少,C3、C4降低的疗效差异无显著性(P>0.05).
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