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Efficacy of clobetasol propionate compound ointment for the treatment of psoriasis vulgaris
Author(s): 
Pages: 310-312
Year: Issue:  5
Journal: JOURNAL OF CLINICAL DERMATOLOGY

Keyword:  银屑病寻常性丙酸氯倍他索维A酸全反式;
Abstract: 目的:观察复方丙酸氯倍他索软膏治疗寻常性银屑病的疗效和安全性.方法:将入组的360例寻常性银屑病患者分为治疗组(复方丙酸氯倍他索软膏组120例)、对照1组(0.02%丙酸氯倍他索霜组120例)和对照2组(0.05%全反式维A酸霜组120例),采用多中心、随机双盲、平行对照的方法对寻常性银屑病患者连续用药4周.结果:3组患者的痊愈率分别为48.33%、18.33%和3.48%,有效率分别为92.50%、50.83%和31.30%.组间比较(试验组与对照1组比较,试验组与对照2组比较)显示,痊愈率和有效率差异均有显著性(P<0.01).试验组和对照1组的不良反应发生率较轻微,对照2组不良反应发生率为11.67%,有3例因不良反应较重中途停止治疗.结论:复方丙酸氯倍他索软膏是一种安全有效的治疗寻常性银屑病的外用药,其疗效优于单用丙酸氯倍他索霜或全反式维A酸霜.
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