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Effects of leflunmide on secretion of TNF-α, IL-6 and IL-8 in HaCaT cell
Author(s): 
Pages: 9-10
Year: Issue:  1
Journal: JOURNAL OF CLINICAL DERMATOLOGY

Keyword:  角质形成细胞HaCaT株来氟米特细胞因子;
Abstract: 目的:研究来氟米特活性代谢产物A77 1726对角质形成细胞分泌α-肿瘤坏死因子(TNF-α),白介素(IL)-6及IL-8的影响.方法:以体外培养的角质形成细胞株HaCaT为对象,以不同浓度A77 1726处理正常及TNF-α刺激后细胞,用生物活性法及ELISA方法测定培养上清中TNF-α、IL-6及IL-8的分泌变化情况.结果:正常情况下,HaCaT细胞可自发分泌TNF-α、IL-6和IL-8;药物作用后分泌水平下降;TNF-α诱导下,HaCaT细胞IL-6及IL-8表达量均增加,加入来氟米特后则表达量均受到抑制.结论:来氟米特可抑制角质形成细胞分泌TNF-α、IL-6及IL-8.
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