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A study on the correlation between clinical features and HLA class Ⅱ genes with vitiligo in the Han nationality of East China
Author(s): 
Pages: 697-699
Year: Issue:  12
Journal: JOURNAL OF CLINICAL DERMATOLOGY

Keyword:  白癜风HLA-Ⅱ类基因临床特征汉族;
Abstract: 目的:探讨华东地区汉族HLA-Ⅱ类基因与白癜风临床特征的相关性.方法:采用聚合酶链反应-序列特异性寡核苷酸探针(PCR-SSOP)方法检测华东地区汉族白癜风患者HLA-DRB1、DQA1和DQB1位点的等位基因,使用SPSS 10.0统计软件分析.结果:HLA-DQA1*0103与伴发内分泌疾病的患者有显著正相关,DRB1*09与C4降低的患者明显负相关.按临床类型分析,发现局限型与DRB1*09和DQA1*03正相关,非节段型与DQA1*03正相关.结论:在华东地区汉族人群中,白癜风的临床特征与HLA-Ⅱ类基因有一定的相关性.
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