Effects of Wenshen Jianpi Recipe hot compress in the treatment of amyotrophic lateral sclerosis: A randomized controlled clinical trial
Author(s): ZHANG Hongzhi, SIMA Dandan, JOANA Schroder, ZHENG Xuanlu, WANG Mingzhe, PAN Weidong, Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Pages: 25-28
Year: 2021 Issue: 4
Journal: Academic Journal of Shanghai University of Traditional Chinese Medicine
Keyword: amyotrophic lateral sclerosis; Wenshen Jianpi Recipe hot compress; integrated traditional Chinese and western medicine; randomized controlled trial;
Abstract: Objective: To observe the efficacy and safety of Wenshen Jianpi Recipe hot compress in the treatment of amyotrophic lateral sclerosis(ALS). Methods: Sixty-nine patients with ALS were selected and randomly divided into the treatment group(n=35) and control group(n=34). The patients in both groups were treated with conventional medicine, and the patients in the treatment group were treated with Wenshen Jianpi Recipe hot compress based on above. The treatment course was 4 months. Before and after treatment, the scores of ALS symptom scale in integrative treatment(ALS-SSIT) and ALS functional rating scale(ALS-FRS) were compared between the two groups, and the safety of treatment was evaluated. Results: In the course of trial, 3 patients in the treatment group and 4 patients in the control group were excluded. Finally 32 cases in the treatment group and 30 cases in the control group were included for the statistical analysis. After treatment, the ALS-SSIT scores in the two groups were increased(P<0.05), while the score of the treatment group was lower than that of the control group(P<0.05). After treatment, the ALS-FRS scores in the two groups were decreased(P<0.05), while the score of the treatment group was higher than that of the control group(P<0.05). In the course of treatment, skin itching caused by Wenshen Jianpi Recipe hot compress was observed in 7 cases. Among, 2 cases discontinued the therapy and 5 cases continued the therapy. Other adverse reactions were not found. Conclusion: As an adjuvant treatment method, Wenshen Jianpi Recipe hot compress may delay the development of ALS symptoms to a certain degree, with good safety.
Pages: 25-28
Year: 2021 Issue: 4
Journal: Academic Journal of Shanghai University of Traditional Chinese Medicine
Keyword: amyotrophic lateral sclerosis; Wenshen Jianpi Recipe hot compress; integrated traditional Chinese and western medicine; randomized controlled trial;
Abstract: Objective: To observe the efficacy and safety of Wenshen Jianpi Recipe hot compress in the treatment of amyotrophic lateral sclerosis(ALS). Methods: Sixty-nine patients with ALS were selected and randomly divided into the treatment group(n=35) and control group(n=34). The patients in both groups were treated with conventional medicine, and the patients in the treatment group were treated with Wenshen Jianpi Recipe hot compress based on above. The treatment course was 4 months. Before and after treatment, the scores of ALS symptom scale in integrative treatment(ALS-SSIT) and ALS functional rating scale(ALS-FRS) were compared between the two groups, and the safety of treatment was evaluated. Results: In the course of trial, 3 patients in the treatment group and 4 patients in the control group were excluded. Finally 32 cases in the treatment group and 30 cases in the control group were included for the statistical analysis. After treatment, the ALS-SSIT scores in the two groups were increased(P<0.05), while the score of the treatment group was lower than that of the control group(P<0.05). After treatment, the ALS-FRS scores in the two groups were decreased(P<0.05), while the score of the treatment group was higher than that of the control group(P<0.05). In the course of treatment, skin itching caused by Wenshen Jianpi Recipe hot compress was observed in 7 cases. Among, 2 cases discontinued the therapy and 5 cases continued the therapy. Other adverse reactions were not found. Conclusion: As an adjuvant treatment method, Wenshen Jianpi Recipe hot compress may delay the development of ALS symptoms to a certain degree, with good safety.
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