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Study on a new synthetic process for the key intermediate of rosuvastatin
Author(s): 
Pages: 763-768
Year: Issue:  3
Journal: Journal of Chemical Engineering of Chinese Universities

Keyword:  瑞舒伐他汀中间体合成硫脲法嘧啶;
Abstract: 研究了一种瑞舒伐他汀关键中间体4-(4-氟苯基)-6-异丙基-2-(N-甲基-N-甲磺酰氨基)嘧啶-5-甲腈合成的新工艺.以硫脲法,经环合、甲基化、氧化、取代等步骤合成目标化合物,并对合成过程中主要步骤进行了工艺优化.主要化合物经1HNMR核磁鉴定.研究结果表明,以不含活泼氢的极性THF为溶剂时,异丁酰乙腈制备的收率高达95.2%;在质子酸和过渡金属盐催化下,经缩合制备了4-(4-氟苯基)-6-异丙基-2-硫代-1,2,3,4-四氢嘧啶-5-甲腈,该步反应的收率可达80%以上;在35℃下,以双氧水为氧化剂,以钨酸钠为催化剂,以甲醇为溶剂时,经氧化制备4-(4-氟苯基)-6-异丙基-2-甲磺酰基嘧啶-5-甲腈的收率最高,为85.2%.
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