Effects of Intensive Insulin Therapy on Serum Inflammatory Factors and Oxidative Stress in Newly Diagnosed Type 2 Diabetic Mellitus Patients
Author(s): Lou Shixian, Liu Xinyu, Zheng Weiying, Department of Endocrinology, Jinhua People’s Hospital
Pages: 792-795
Year: 2019 Issue: 12
Journal: Chinese Journal of Pharmacoepidemiology
Keyword: Type 2 diabetes; Intensive insulin therapy; Inflammatory cytokines; Oxidative stress;
Abstract: Objective:To investigate the effects of intensive insulin therapy on serum inflammatory factors and oxidative stress in newly diagnosed type 2 diabetes mellitus(T2 DM) patients. Methods:A total of 75 cases of newly diagnosed T2 DM patients were divided into control group(35 cases) and observation group(40 cases) according to the random number table method, the patients in the control group were treated with metformin orally, the patients in the observation group were given insulin pump intensive treatment. After 2 weeks of treatment, the levels of blood glucose, glycosylated hemoglobin(HbA1 c) and the time of blood glucose reaching target, as well as the change of inflammatory factors and oxidative stress levels before and after treatment in the two groups were compered. Results:The levels of fasting blood sugar(FPG), 2 h postprandial blood glucose(2 hPG) and HbA1 c in the two groups were significantly lower than those before treatment(P<0.05), and the levels of FPG, 2 hPG and HbA1 c in the observation group were significantly lower than those in the control group(P<0.05); The time of blood glucose reaching target was significantly shorter than that of the control group(P<0.05); After treatment, the levels of C-reactive protein(CRP), interleukin-6(IL-6), tumor necrosis factor-alpha(TNF-α) and plasma malondialdehyde(MDA) in the two groups were significantly decreased(P<0.05), and the levels of superoxide dismutase(SOD) and reduced glutathione(RGSH) in the two groups were significantly increased(P<0.05); In addition, the observation group was significantly better than the control group in all other indicators except RGSH(P<0.05). Conclusion: Insulin pump intensive treatment can significantly improve the treatment of newly diagnosed T2 DM patients, shorten the time of blood glucose reaching target, reduce inflammation and oxidative stress, which is worth popularizing in clinical application.
Pages: 792-795
Year: 2019 Issue: 12
Journal: Chinese Journal of Pharmacoepidemiology
Keyword: Type 2 diabetes; Intensive insulin therapy; Inflammatory cytokines; Oxidative stress;
Abstract: Objective:To investigate the effects of intensive insulin therapy on serum inflammatory factors and oxidative stress in newly diagnosed type 2 diabetes mellitus(T2 DM) patients. Methods:A total of 75 cases of newly diagnosed T2 DM patients were divided into control group(35 cases) and observation group(40 cases) according to the random number table method, the patients in the control group were treated with metformin orally, the patients in the observation group were given insulin pump intensive treatment. After 2 weeks of treatment, the levels of blood glucose, glycosylated hemoglobin(HbA1 c) and the time of blood glucose reaching target, as well as the change of inflammatory factors and oxidative stress levels before and after treatment in the two groups were compered. Results:The levels of fasting blood sugar(FPG), 2 h postprandial blood glucose(2 hPG) and HbA1 c in the two groups were significantly lower than those before treatment(P<0.05), and the levels of FPG, 2 hPG and HbA1 c in the observation group were significantly lower than those in the control group(P<0.05); The time of blood glucose reaching target was significantly shorter than that of the control group(P<0.05); After treatment, the levels of C-reactive protein(CRP), interleukin-6(IL-6), tumor necrosis factor-alpha(TNF-α) and plasma malondialdehyde(MDA) in the two groups were significantly decreased(P<0.05), and the levels of superoxide dismutase(SOD) and reduced glutathione(RGSH) in the two groups were significantly increased(P<0.05); In addition, the observation group was significantly better than the control group in all other indicators except RGSH(P<0.05). Conclusion: Insulin pump intensive treatment can significantly improve the treatment of newly diagnosed T2 DM patients, shorten the time of blood glucose reaching target, reduce inflammation and oxidative stress, which is worth popularizing in clinical application.
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