Influence of Tongxie Sishen decoction combined with trimebutine maleate and oryzanol on serum IFN-γ,5-HT,NPY levels and T lymphocyte subsets in patients with diarrhea predominant irritable bowel syndrome
Author(s): CHEN Guang-hua, LI Hong-jun, SHU Bo, The Affiliated Hospital of North Sichuan Medical College
Pages: 742-746
Year: 2018 Issue: 9
Journal: Chinese Journal of Integrated Traditional and Western Medicine on Digestion
Keyword: Tongxie Sishen decoction; trimebutine maleate; oryzanol; irritable bowel syndrome;
Abstract: [Objective]To analyze the influence of Tongxie Sishen decoction combined with trimebutine maleate and oryzanol on serum interferon gamma(IFN-γ),5 hydroxytryptamine(5-HT),neuropeptide Y(NPY)levels and T lymphocyte subsets in the patients with diarrhea predominant irritable bowel syndrome(IBS-D).[Methods]Ninety-eight patients with IBS-D were selected and randomly divided into the control group and the observation group,forty-nine cases in each group,the control group were treated with trimebutine maleate and oryzanol treatment,on the basisof this,the observation group were treated with Tongxie Sishen decoction,the changes of TCM symptom scores before and after the treatment,clinical efficacy,the changes of IFN-γ,5-HT,NPY,T lymphocyte subsets levels and the incidence rate of adverse reactions were observed and recorded in the two groups.[Results]After treatment,the TCM symptom score of the observation group was significantly lower than that of the control group(P<0.05);the total effective rate of the observation group was significantly higher than that of the control group(P<0.05);the levels of IFN-γ,5-HT and NPY in the two groups were significantly decreased(P<0.05),and the changes of the indexes in the observation group were significantly higher than those in the control group(P<0.05);after treatment,the CD3~+,CD4~+levels and CD4~+/CD8~+of T lymphocyte subsets in the two groups were significantly increased(P<0.05),the CD8~+level decreased significantly(P<0.05),and the changes of the indexes in the observation group were greater than those in the control group(P<0.05);the incidence rate of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).[Conclusion]Tongxie Sishen decoction combined with trimebutine maleate and oryzanol in the treatment of IBS-D can effectively reduce the serum IFN-γ,5-HT and NPY levels,improve T lymphocyte CD3~+,CD4~+,CD8~+levels and CD4~+/CD8~+,and the risk of adverse reaction is low,the curative effect is significant.
Pages: 742-746
Year: 2018 Issue: 9
Journal: Chinese Journal of Integrated Traditional and Western Medicine on Digestion
Keyword: Tongxie Sishen decoction; trimebutine maleate; oryzanol; irritable bowel syndrome;
Abstract: [Objective]To analyze the influence of Tongxie Sishen decoction combined with trimebutine maleate and oryzanol on serum interferon gamma(IFN-γ),5 hydroxytryptamine(5-HT),neuropeptide Y(NPY)levels and T lymphocyte subsets in the patients with diarrhea predominant irritable bowel syndrome(IBS-D).[Methods]Ninety-eight patients with IBS-D were selected and randomly divided into the control group and the observation group,forty-nine cases in each group,the control group were treated with trimebutine maleate and oryzanol treatment,on the basisof this,the observation group were treated with Tongxie Sishen decoction,the changes of TCM symptom scores before and after the treatment,clinical efficacy,the changes of IFN-γ,5-HT,NPY,T lymphocyte subsets levels and the incidence rate of adverse reactions were observed and recorded in the two groups.[Results]After treatment,the TCM symptom score of the observation group was significantly lower than that of the control group(P<0.05);the total effective rate of the observation group was significantly higher than that of the control group(P<0.05);the levels of IFN-γ,5-HT and NPY in the two groups were significantly decreased(P<0.05),and the changes of the indexes in the observation group were significantly higher than those in the control group(P<0.05);after treatment,the CD3~+,CD4~+levels and CD4~+/CD8~+of T lymphocyte subsets in the two groups were significantly increased(P<0.05),the CD8~+level decreased significantly(P<0.05),and the changes of the indexes in the observation group were greater than those in the control group(P<0.05);the incidence rate of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).[Conclusion]Tongxie Sishen decoction combined with trimebutine maleate and oryzanol in the treatment of IBS-D can effectively reduce the serum IFN-γ,5-HT and NPY levels,improve T lymphocyte CD3~+,CD4~+,CD8~+levels and CD4~+/CD8~+,and the risk of adverse reaction is low,the curative effect is significant.
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