Author(s): LEI Chun-pu, HOU Wen-jun, LI Xin-fu
Pages: 1336-1338
Year: 2018 Issue:  12
Journal: Journal of Clinical and Experimental Medicine
Keyword:  Irritable bowel syndrome; Doxepin; Oryzanol; Dicetel; Clinical effect;
Abstract: Objective To evaluate the effect of Doxepin combined with Oryzanol for irritable bowel syndrome. Methods One hundred and twenty patients with irritable bowel syndrome who were treated in the Armed Police General Hospital from August 2015 to October 2017 were randomly divided into observation group (n=60)and control group (n=60)using random number table method. The observation group received Doxepin combined with Oryzanol for treatment,while control group received Dicetel. Both groups were given psychological care. The clinical effect,adverse events and the improvement of mental state were compared between the two groups. Results The total clinical effective rate of ob-servation group (95.0％)was significantly higher than control group (83.3％)(χ2=4.23,P<0.05). Adverse reaction rate of observation group was slightly higher than that of control group (χ2=0.15,P>0.05). After 6 weeks of treatment,the psychological quantitative score of the observation group was significantly lower than that of the control group. Conclusion The effect of Doxepin combined with Oryzanol for irritable bowel syndrome is superior to that of Dicetel. The incidence of adverse reactions of Doxepin combined with Oryzanol was roughly equal to that of Dicetel. Meanwhile,Doxepin combined with Oryzanol can effectively improve the patient's mental state.