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The association of polymorphism of tumor necrosis factor receptor 2 gene with the susceptibility to systemic lupus erythematosus
Author(s): 
Pages: 746-748
Year: Issue:  12
Journal: JOURNAL OF CLINICAL DERMATOLOGY

Keyword:  肿瘤坏死因子受体2红斑狼疮系统性相关性;
Abstract: 为探讨肿瘤坏死因子受体2(TNF R2)第六外显子基因多态性与系统性红斑狼疮(SLE)易感的相关性,采用病例对照研究的方法,用聚合酶链反应-限制性片段长度多态性分析技术(PCR-RFLP)检测50例SLE患者和117例健康对照人群的TNF R2第六外显子的基因型和等位基因,SLE患者组TNF R2第六外显子基因型196R/R、196M/R和等位基因196R的频率明显比对照组高,经χ2检验,其差异具有统计学意义.(两组基因型之间:χ2=6.23P=0.044;两组等位基因之间:χ2=6.39 P=0.011).结果表明TNF R2第六外显子基因多态性与SLE的易感性相关.
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