Effect of probiotics treatment on prevention of chemotherapy and radiation-related diarrhea among cancer patients:a Meta-analysis of randomized controlled trials
Author(s): CAO Mingli, WANG Miao, SONG Fengju, Department of Chronic Diseases, Hexi District Center for Disease Control and Prevention, Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital
Pages: 650-656+680
Year: 2017 Issue: 6
Journal: Tumor
Keyword: Neoplasms; Probiotics; Diarrhea; Drug therapy; Radiation therapy;
Abstract: Objective:To evaluate the effect of probiotics on prevention of chemotherapy and radiation-related diarrheas among cancer patients.Methods:Literature search in PubMed,Embase,ClinicalTrials.gov and Cochrane Library was administered to collect the randomized controlled trials on the use of probiotics in the treatment of cancer patients with chemotherapy and radiation-related diarrheas by the end of January 2017.The quality evaluation of selected literatures was evaluated.Stata 12.0 software was used for Meta-analysis,and Egger test was used to determine the publication bias.Results:A total of 9 randomized controlled studies were included.Total of 735 patients with malignant tumors received probiotics after chemotherapy and radiotherapy,and 695 patients with malignant tumors received placebo.The result of Meta-analysis showed that as compared with the control group,the probiotics treatment in patients with malignant tumors after chemotherapy and radiotherapy can significantly reduce the incidence rate of diarrhea by 33%(95% confidence interval:13% to 49%;P=0.003);radiotherapy-related diarrhea was significantly reduced by 31%(95% confidence interval:7% to 49%)(P=0.020),and the chemotherapy-related diarrhea was decreased by 53%(95% confidence interval:37% to 84%)(P=0.170).Conclusion:Probiotics treatment after chemotherapy and radiotherapy in patients with malignant tumors can significantly reduce the incidence rate of diarrhea,mainly to reduce the incidence rate of radiation-related diarrhea,and whether it can reduce the chemotherapyrelated diarrhea still need further evidence to support.
Pages: 650-656+680
Year: 2017 Issue: 6
Journal: Tumor
Keyword: Neoplasms; Probiotics; Diarrhea; Drug therapy; Radiation therapy;
Abstract: Objective:To evaluate the effect of probiotics on prevention of chemotherapy and radiation-related diarrheas among cancer patients.Methods:Literature search in PubMed,Embase,ClinicalTrials.gov and Cochrane Library was administered to collect the randomized controlled trials on the use of probiotics in the treatment of cancer patients with chemotherapy and radiation-related diarrheas by the end of January 2017.The quality evaluation of selected literatures was evaluated.Stata 12.0 software was used for Meta-analysis,and Egger test was used to determine the publication bias.Results:A total of 9 randomized controlled studies were included.Total of 735 patients with malignant tumors received probiotics after chemotherapy and radiotherapy,and 695 patients with malignant tumors received placebo.The result of Meta-analysis showed that as compared with the control group,the probiotics treatment in patients with malignant tumors after chemotherapy and radiotherapy can significantly reduce the incidence rate of diarrhea by 33%(95% confidence interval:13% to 49%;P=0.003);radiotherapy-related diarrhea was significantly reduced by 31%(95% confidence interval:7% to 49%)(P=0.020),and the chemotherapy-related diarrhea was decreased by 53%(95% confidence interval:37% to 84%)(P=0.170).Conclusion:Probiotics treatment after chemotherapy and radiotherapy in patients with malignant tumors can significantly reduce the incidence rate of diarrhea,mainly to reduce the incidence rate of radiation-related diarrhea,and whether it can reduce the chemotherapyrelated diarrhea still need further evidence to support.
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