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The efficacy of 830nm IR-A combined with 308nm monochromatic excimer light for vitiligo
Pages: 251-255
Year: Issue:  4
Journal: Journal of Clinical Dermatology

Keyword:  830 nm近红外光308 nm单频准分子光白癜风;
Abstract: Objective: To investigate the clinical efficacy of 830 nm near infrared ray(IR-A) radiation combined with 308 nm monochromatic excimer light(MEL) for vitiligo. Methods: A total of 123 vitiligo patients with depigmented area≤10% of the total skin area were randomly divided into 3 groups, i.e, IR-A, MEL, and combination of IR-A and MEL treatment. Patients were treated twice weekly for 12 weeks. Result: Treatments with combination of IR-A and MEL yielded significantly higher effective rates than that with either IR-A or MEL alone(effective rates: 72.5% for combination of IR-A and MEL;25.0% for IR-A; 47.5% for MEL). In addition, repigmentation appeared earlier in patients treated with combination of IR-A and MEL than in patients treated with either IR-A or MEL alone. Adverse reactions included erythema, mild pruritus and others. IR-A-induced adverse reactions were negligible, while MEL induced severe side effects, which disappeared slowly. In contrast, combination of IR-A and MEL caused mild side effects, which disappeared rapidly and spontaneously. Conclusion:Combination of IR-A and MEL(UVB) can improve the therapeutic efficacy for vitiligo, rapidly induce repigmentation, and reduce the severity of adverse effects.
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