Research Progress on Chemical Constituents and Biological Activity of Nothapodytes nimmoniana
Author(s): SHEN Rui-chi, WU Mei-fang, HE En-ming, CHEN De-lin, WANG Jie, HE Jian-zhang, ZHOU Shuang
Pages: 379-385
Year: 2016 Issue: 4
Journal: Subtropical Plant Science
Keyword: Nothapodytes nimmoniana; camptothecin; chemical constituents; biological activity; extraction;
Abstract: Camptothecin (CPT) is a cytotoxic quinoline alkaloid which is only one specially inhibiting the DNA enzyme topoisomerase I (topo I), showes remarkable anticancer activity. There are many CPTs and other active ingredients in Nothapodytes nimmoniana, the contents of CPT, 9-methoxycamptothecin and hydroxycamptothecin in Nothapodytes nimmoniana are most abundant. N. nimmoniana have become an important medicinal plant. In this paper, the chemical constituents, their biological activity and extraction methods of N. nimmoniana were summarized. In addition, the development and utilization prospect of N. nimmoniana were introduced.
Pages: 379-385
Year: 2016 Issue: 4
Journal: Subtropical Plant Science
Keyword: Nothapodytes nimmoniana; camptothecin; chemical constituents; biological activity; extraction;
Abstract: Camptothecin (CPT) is a cytotoxic quinoline alkaloid which is only one specially inhibiting the DNA enzyme topoisomerase I (topo I), showes remarkable anticancer activity. There are many CPTs and other active ingredients in Nothapodytes nimmoniana, the contents of CPT, 9-methoxycamptothecin and hydroxycamptothecin in Nothapodytes nimmoniana are most abundant. N. nimmoniana have become an important medicinal plant. In this paper, the chemical constituents, their biological activity and extraction methods of N. nimmoniana were summarized. In addition, the development and utilization prospect of N. nimmoniana were introduced.
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