Association between CDH23 gene polymorphisms and susceptibility to noise-induced hearing loss in the Chinese population: a meta-analysis
Author(s): YU Jinning, WU Shanshan, HE Chunhong, ZHANG Changyun, MOU Hongxiang, MA Weisheng, LIU Bo, ZHANG Yan, YU Shanfa
Pages: 920-923
Year: 2016 Issue: 12
Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases
Keyword: Noise; occupational; Hearing loss; Occupational health; Susceptibility;
Abstract: Objective To investigate the association between cadherin-23 (CDH23) gene polymorphisms and susceptibility to noise-induced hearing loss (NIHL) in the Chinese population through a meta-analysis.Methods In June 2016,CNKI,VIP,Wanfang Data,and PubMed were searched for studies on the association between CDH23 gene polymorphisms and susceptibility to NIHL in the Chinese population.The articles were screened according to inclusion and exclusion criteria and related data were extracted.RevMan 5.3 was used for the meta-analysis.Results A total of three Chinese articles were included.For CDH23-rs1227049,the risk of NIHL in people with C allele was 0.82 times (95％CI 0.39-1.73) that in people with G allele,the risk of NIHL in people with CG+CC genotype in the dominant model was 0.70 times (95％CI 0.34-1.43) that in people with GG genotype,the risk of NIHL in people with CC genotype in the recessive model was 1.23 times (95％CI 0.28-5.43) that in people with CG+GG genotype,and the risk of NIHL in people with CC genotype in the additive model was 1.05 times (95％CI 0.20-5.44) that in people with GG genotype (all P＞0.05).For CDH23-rs1227051,the risk of NIHL in people with T allele was 0.98 times (95％CI 0.71-1.37) that in people with C allele,and the risk of NIHL in people with CT+CC genotype in the dominant model was 1.09 times (95％CI 0.75-1.57) that in patients with TT genotype (both P＞0.05).Conclusion There is still no enough evidence for the determination of CDH23-rs1227049 and CDH23-rs1227051 to be the susceptibility gene loci of NIHL.
Pages: 920-923
Year: 2016 Issue: 12
Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases
Keyword: Noise; occupational; Hearing loss; Occupational health; Susceptibility;
Abstract: Objective To investigate the association between cadherin-23 (CDH23) gene polymorphisms and susceptibility to noise-induced hearing loss (NIHL) in the Chinese population through a meta-analysis.Methods In June 2016,CNKI,VIP,Wanfang Data,and PubMed were searched for studies on the association between CDH23 gene polymorphisms and susceptibility to NIHL in the Chinese population.The articles were screened according to inclusion and exclusion criteria and related data were extracted.RevMan 5.3 was used for the meta-analysis.Results A total of three Chinese articles were included.For CDH23-rs1227049,the risk of NIHL in people with C allele was 0.82 times (95％CI 0.39-1.73) that in people with G allele,the risk of NIHL in people with CG+CC genotype in the dominant model was 0.70 times (95％CI 0.34-1.43) that in people with GG genotype,the risk of NIHL in people with CC genotype in the recessive model was 1.23 times (95％CI 0.28-5.43) that in people with CG+GG genotype,and the risk of NIHL in people with CC genotype in the additive model was 1.05 times (95％CI 0.20-5.44) that in people with GG genotype (all P＞0.05).For CDH23-rs1227051,the risk of NIHL in people with T allele was 0.98 times (95％CI 0.71-1.37) that in people with C allele,and the risk of NIHL in people with CT+CC genotype in the dominant model was 1.09 times (95％CI 0.75-1.57) that in patients with TT genotype (both P＞0.05).Conclusion There is still no enough evidence for the determination of CDH23-rs1227049 and CDH23-rs1227051 to be the susceptibility gene loci of NIHL.
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