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Effect of prolonged radiation treatment time on survival in nasopharyngeal carcinoma patients treated with IMRT combined with chemotherapy
Author(s): 
Pages: 48-51
Year: Issue:  1
Journal: New Chinese Medicine

Keyword:  Nasopharyngeal carcinomaIntensity-modulated radiotherapyChemotherapyRadiation treatment timeOverall survival;
Abstract: Objective To evaluate the effect of prolonged radiation treatment time (RTT)upon the survival of nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy (IMRT)com-bined with chemotherapy.Methods Clinical data of 629 patients diagnosed with nasopharyngeal carcinoma were retrospectively analyzed.All enrolled patients received IMRT combined with chemotherapy.The influence of prolonged RTT upon the survival of patients was assessed by Kaplan-Meier survival analysis.Clinical progno-sis was evaluated by Cox regression analysis.Results The RTT for 629 nasopharyngeal carcinoma patients ranged from 37 to 59 d with a median of 44 d.Compared with patients treated with RTT≤44 d,the overall sur-vival of patients treated with RTT > 44 d was significantly lower (HR =1.88,95% CI 1.12-3.15,P =0.014),and the risk of distant metastasis was slightly higher without statistical significance (P =0.069).Cox regression analysis demonstrated that RTT was an independent risk factor of overall survival of nasopharyngeal carcinoma patients (HR =1.04,95%CI 1.01-1.08,P =0.021).Conclusion Prolonged RTT (>44 d) can decrease the survival of patients with nasopharyngeal carcinoma.
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