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Study on expression of Fas,Bax antigens in lupus nephritis tissues
Author(s): 
Pages: 282-283
Year: Issue:  5
Journal: JOURNAL OF CLINICAL DERMATOLOGY

Keyword:  狼疮性肾炎Fas抗原Bax抗原;
Abstract: 为探讨Fas、Bax抗原的表达与狼疮性肾炎(lupus nephritis,LN)发病过程之间的关系,用免疫组化方法检测狼疮肾活检标本石蜡切片中Fas、Bax抗原的表达情况.狼疮性肾炎Bax抗原阳性表达率为70%,肾小管、肾小球、间质三个部位均有阳性表达; Fas抗原阳性表达率为75%,阳性表达仅见于肾小管;Fas、Bax阳性表达与LN病理分型间无明显的相关性(P>0.05 ).促凋亡基因的过度表达,可能是狼疮性肾炎的发生、发展的重要因素.
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