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Clinical efficacy of esmolol on myocardial protection in pediatrics with congenital heart disease
Author(s): MuYa-ning, Bai Jin, Huang Caihong, Zhang Xiaoxing
Pages: 628-
632
Year: 2016
Issue:
9
Journal: New Chinese Medicine
Keyword: Esmolol; Congenital heart defect; Children; Myocardial protection;
Abstract: Objective To evaluate the clinical efficacy of esmolol on myocardial protection in pediat-rics diagnosed with congenital heart disease.Methods Ninety pediatric patients scheduled to undergo the sur-gery of congenital heart disease were chosen and randomly divided into groups A and B(n =45 for each group). For the patients in the group A,1 .5 ml of esmolol at a dose of 250 mg/ml was supplemented to 1 L of St. Thomas’Ⅱ solution,and an equivalent quantity of normal saline was added in the group B.Systolic arterial blood pressure,central venous pressure (CVP),heart rate,the administration amount of dopamine and epi-nephrine were recorded within 4 h after surgery.Left ventricle ejection fraction (LVEF)and cardiac output (CO)were measured at 1 d and 1 week following surgery.Results There was no significant difference in the cardiopulmonary bypass,time of extubation and length of ICU stay between two groups (all P >0.05).In the group A,39 patients (87%)were administered with the inotrope after surgery,significantly lower than 45 (1 00%)in the group B (P =0.026).Intraoperatively,the CK-MB level in the group A was (92.1 ±2.1 ) U /L,significantly lower compared with (1 1 0.9 ±4.5) U /L in the group B (P <0.05).Furthermore,the LVEF and CO in the group A were considerably higher than and in the group B at postoperative 1 week (both P<0.05).Conclusions Esmolol exerts effective effect upon myocardial protection in pediatrics with congenital heart disease,which can reduce postoperative use of inotrope,mitigate the severity of myocardial damage and increase the LVEF and CO at postoperative 1 week.
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