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Correlation between electroencephalogram characteristics and clinical symptoms in children with au-tism spectrum disorder
Author(s): Zhou Yan, Zhang Gong, Deng Hongzhu, Zou Xiaobing
Pages: 527-
535
Year: 2016
Issue:
8
Journal: New Chinese Medicine
Keyword: Autism spectrum disorder; Children; Electroencephalogram; Brain electrical activity mapping; Clinical symptom;
Abstract: Objective To analyze the correlation between electroencephalogram (EEG)characteris-tics and clinical symptoms in children diagnosed with autism spectrum disorder (ASD),aiming to provide ref-erence for early diagnosis and intervention of ASD.Methods Forty one ASD children,aged 17 to 84 months, received routine EEG.All children were divided into the normal EEG (normal group)and abnormal EEG groups (abnormal group)according to the EEG results.Those in the abnormal group further underwent brain e-lectrical activity mapping (BEAM)to analyze the correlation between EEG characteristics and clinical symp-toms (according to autism treatment evaluation scale).Results Among 41 children,28 (68.3%)had nor-mal EEG and 13 (31.7%)yielded abnormal EEG.In the normal group,the mean autism treatment evaluation checklist (ATEC)score was (73.4 ±23.4),which did not significantly differ from (63.5 ±24.2)in the ab-normal group (P >0.05).In the abnormal group,the δabsolute power at the right anterior temporal region was positively correlated with the consciousness/cognition score of autism treatment evaluation scale (r =0.575,P =0.040).In the abnormal group,the δabsolute power at bilateral frontal region in children aged <36 months and > 60 months was significantly higher compared with that in those aged between 36 and 60 months.The θabsolute power at bilateral frontal region was significantly higher than that in their counterparts aged 36 to 60 months (both P <0.05 /3).Conclusions The higher the δabsolute power at the right anterior region,the more severe cognition disorder in ASD children.Abnormal discharge from the frontal neurons differs over age.
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