Diagnostic value of combined measurement of metastasis-associated in colon cancer 1 and mesenchymal-epithelial transition factor in lung adenocarcinoma patients with malignant pleural effusion
Author(s): Hu Jie, You Qinghai, Sun Gengyun
Pages: 120-124
Year: 2016 Issue: 2
Journal: Chinese Journal of lung Disease（Electronic Edition）
Keyword: Lung adenocarcinoma; Metastasis-associated in colon cancer 1; Mesenchymal-epithelial transition factor; Carcino embryonie antigen; Malignant pleural effusion;
Abstract: 目的 探讨结肠癌转移相关因子-1 (MACC1)、间质-上皮细胞转化因子(c-MET)联合癌胚抗原(CEA)在肺腺癌患者并发恶性胸腔积液中的诊断价值.方法 将91例胸腔积液患者(良性38例,肺腺癌53例)纳入研究,采用ELISA法测定血清和胸腔积液中MACC1、c-MET浓度,放射免疫法测定CEA浓度.结果 肺腺癌患者恶性胸腔积液中MACC1、c-MET和CEA浓度明显高于良性患者胸腔积液中的含量(P＜0.05);两组患者血清中MACC1和c-MET浓度无统计学差异(P＞0.05).胸腔积液中MACC1和c-MET含量呈正相关(r=0.728,P＜0.01).根据ROC曲线,以MACC1浓度90.98 pg/ml为临界值,对肺腺癌患者并发恶性胸腔积液的诊断灵敏度为62.26％,特异度为84.21％;c-MET浓度757.67ng/ml为临界值,肺腺癌患者恶性胸腔积液的诊断灵敏度为52.83％,特异度为84.21％.MACC1联合c-MET检测灵敏度为75.47％,特异度为92.11％;MACC1、c-MET联合CEA诊断的灵敏度为98.10％,特异度为100％.结论 MACC1和c-MET在肺腺癌患者并发恶性胸腔积液的诊断中具有一定价值,联合CEA检测可明显提高诊断的灵敏度和特异度.
Pages: 120-124
Year: 2016 Issue: 2
Journal: Chinese Journal of lung Disease（Electronic Edition）
Keyword: Lung adenocarcinoma; Metastasis-associated in colon cancer 1; Mesenchymal-epithelial transition factor; Carcino embryonie antigen; Malignant pleural effusion;
Abstract: 目的 探讨结肠癌转移相关因子-1 (MACC1)、间质-上皮细胞转化因子(c-MET)联合癌胚抗原(CEA)在肺腺癌患者并发恶性胸腔积液中的诊断价值.方法 将91例胸腔积液患者(良性38例,肺腺癌53例)纳入研究,采用ELISA法测定血清和胸腔积液中MACC1、c-MET浓度,放射免疫法测定CEA浓度.结果 肺腺癌患者恶性胸腔积液中MACC1、c-MET和CEA浓度明显高于良性患者胸腔积液中的含量(P＜0.05);两组患者血清中MACC1和c-MET浓度无统计学差异(P＞0.05).胸腔积液中MACC1和c-MET含量呈正相关(r=0.728,P＜0.01).根据ROC曲线,以MACC1浓度90.98 pg/ml为临界值,对肺腺癌患者并发恶性胸腔积液的诊断灵敏度为62.26％,特异度为84.21％;c-MET浓度757.67ng/ml为临界值,肺腺癌患者恶性胸腔积液的诊断灵敏度为52.83％,特异度为84.21％.MACC1联合c-MET检测灵敏度为75.47％,特异度为92.11％;MACC1、c-MET联合CEA诊断的灵敏度为98.10％,特异度为100％.结论 MACC1和c-MET在肺腺癌患者并发恶性胸腔积液的诊断中具有一定价值,联合CEA检测可明显提高诊断的灵敏度和特异度.
Related Articles