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Research Progress of Signal Transduction Pathway in Golgi Stress
Pages: 112-116
Year: Issue:  2
Journal: Acta Laser Biology Sinica

Keyword:  Golgi stressphosphoinositideprotein kinase C/protein kinase DRAS/MAPK kinasecAMP/PKA ki-naseresearch progress;
Abstract: Golgi stress is caused by the stress reaction of cerebral ischemia and reperfusion,which lead to the change of the function of the protein processing and transportation and secretion of Golgi protein.Golgi stress is closely related to variety signal transduction pathway in cells.We review the related literature in recent years,and summarize the research progress,The results indicated that Golgi stress plays a role by the signal pathway of phosphoinositide,protein kinase C/protein kinase D,RAS/MAPK kinase,cAMP/PKA kinase,and so on.It is involved in the pathogenesis of ischemic stroke,spinal cord injury,and neurodegenerative diseases.
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