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Research progress of allopurinol-induced hypersensitivity
Author(s): Chen Zena, Gu Jieruo
Pages: 142-
145
Year: 2016
Issue:
3
Journal: New Chinese Medicine
Keyword: Allopurinol; Hypersensitivity;
Abstract: Allopurinol is one of the most common drugs for decreasing the serum uric acid,and also highly likely to cause severe adverse reactions.Based upon pharmacogenetics and immunological findings, HLA-B*58∶01 was intimately correlated with serious allopurinol-induced adverse reaction,which significantly differed among different populations.In addition,HLA-B*58∶01 gene was neither a sufficient nor necessary factor for allopurinol-related supersensitivity.Currently,HLA-B*58∶01 detection was utilized to predict the incidence of allopurinol-related supersensitivity.However,the application value remains to be further elucida-ted.In this article,pharmacogenetics and immunological studies related to allopurinol-related supersensitivity were summarized.
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