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Effects of Shikonin on Th17 related cytokines in psoriasis-like mouse model
Author(s): 
Pages: 323-327
Year: Issue:  5
Journal: Journal of Clinical Dermatology

Keyword:  psoriasisshikoninMTXmouse;
Abstract: Objective: To investigate the effects of shikonin on Th17 related cytokines in psoriasis-like mouse model.Methods: Six to eight-week-old female BALB/c mice were randomly divided into blank controls group, low-dose shikonin,high-dose shikonin, MTX and untreated psoriasis-like mice. Psoriasis area and severity index(PASI) score was used to assess changes in skin lesions. Light microscope was used to evaluate morphological changes and to measure the epidermal thickness. The levels of serum cytokines were detected by ELISA. Results: Imiquimod treatment induced typical psoriasis-like skin lesions such as erythema, scales, and thickening. PASI scores increased gradually, followed by a gradual decline over the course. PASI scores were improved after treatments with either shikonin or MTX. Imiquimod-induced morphological changes included epidermal hyperkeratosis, parakeratosis, and acanthosis. Treatments with either shikonin or MTX significantly reduced epidermal thickness(P<0.01). Similarly, treatments with either shikonin or MTX significantly lowered serum levels of IL-17、IL-17F、TNFα、IL-6 and IL-22(all P<0.05, vs. untreated psoriasis-like mice). Conclusion:Shikonin could significantly improve skin lesions and lowered the serum levels of Th17 related cytokines in psoriasis-like mouse model.
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