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Mixed Rosai-Dorfman disease: a case report and review of literatures
Pages: 353-356
Year: Issue:  5
Journal: Journal of Clinical Dermatology

Keyword:  Rosai-Dorfman diseasemixed type;
Abstract: A case of mixed Rosai-Dorfman disease is reported. A 12-year-old boy presented with subcutaneous mass on the upper eyelid for 1 year and post-surgery recurrence for 1 month. Physical examination revealed subcutaneous masses on the upper eyelid, gills and the lateral lower jaw. The masses were irregular sized 3-5 cm in diameter, soft texture with defined borders, no pain and no tenderness with normal surface skin. Histopathological examination of subcutaneous mass from the left lower jaw revealed benign lymphadenopathy with histiocytoma-like hyperplasia accompanied by disappearance of the lymphatic sinus. Intact lymphocytes and neutrophils could be found in the cytoplasm of some enlarged histiocytes. Immunohistochemistry showed that hyperplastic histiocytes were positive for S-100 protein, CD163 and CD68, and negative for CD1α.According to clinical and pathological features, the final diagnosis was mixed Rosai-Dorfman disease.
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