Identiifcation of Complex Vertebral Malformation (CVM) Carriers in Holstein Cows from Miyun Farms in Beijing
Author(s): LIANG Ruo-bing, ZHAO Xiao-lin, SUN Dong-xiao, ZHANG Yi, ZHANG Sheng-li, WEN Fu-yong
Pages: 15-17,18
Year: 2015 Issue: 19
Journal: China Dairy Cattle
Keyword: Holstein cow; Genetic defects;
Abstract: Complex vertebral malformation (CVM) is a monogenic autosomal recessive hereditary defect of Holstein dairy cattle. It is caused by single base mutation at the 4 extron in bovine solute carrier family 35, member 3 gene (SLC35A3). Homozygous recessive can cause early pregnancy abortion, stillbirth, or calf-birth deformities, but carriers are normal. Polymerase chain reaction–primer introduced restriction analysis (PIRA-PCR) was used to detect CVM among 500 Holstein cows from Miyun farms. As a result, none of carriers were identiifed. Based on this, we had preliminary understanding about the distribution of CVM carriers in Beijing, and provide the basis for CVM genetic defect monitoring and reasonable selection.
Pages: 15-17,18
Year: 2015 Issue: 19
Journal: China Dairy Cattle
Keyword: Holstein cow; Genetic defects;
Abstract: Complex vertebral malformation (CVM) is a monogenic autosomal recessive hereditary defect of Holstein dairy cattle. It is caused by single base mutation at the 4 extron in bovine solute carrier family 35, member 3 gene (SLC35A3). Homozygous recessive can cause early pregnancy abortion, stillbirth, or calf-birth deformities, but carriers are normal. Polymerase chain reaction–primer introduced restriction analysis (PIRA-PCR) was used to detect CVM among 500 Holstein cows from Miyun farms. As a result, none of carriers were identiifed. Based on this, we had preliminary understanding about the distribution of CVM carriers in Beijing, and provide the basis for CVM genetic defect monitoring and reasonable selection.
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