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Clinicopathological analysis of five cases of atrophic dermatofibrosarcoma protuberans
Pages: 535-538
Year: Issue:  9
Journal: Journal of Clinical Dermatology

Keyword:  dermatofibrosarcoma protuberansatrophicclinicopathological analysis;
Abstract: Objective: To investigate the clinicopathological features of atrophic dermatofibrosarcoma protuberans(DFSP).Method:The clinical and pathological data of 5 cases of atrophic DFSP were retrospectively analyzed. Results: Lesions were mainly manifested by slow-growing, demarcated atrophic plaques. Subcutaneous nodules or nodules on atrophic erythematous plaques were also observed. DFSP could be easily misdiagnosed. Four cases were misdiagnosed with morphea. The histopathological features of atrophic DFSP included dermal atrophy and dermal tumor cells with or without infiltration into adipose tissue, arranged in parallel to the epidermis. Immunohistochemically, the neoplastic cells were positive for CD34, and negative for CD68 and S-100. Conclusion: In contrast to classic DFSP, atrophic DFSP shows atrophic plaques without nodules, which can easily lead to misdiagnosis. Pathological features of atrophic dermis and tumor cells arranged in a non-storiform pattern could be misdiagnosed as a scar or as fibrous cell tumors.
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