Effect of Fuyuanxingnao Decoction combined with western medicine on lacunar infarction and their impact on the levels of IL-6, TNF-αand NO
Author(s): WANG Liping, LIU Cuimei, ZHANG Hong
Pages: 3207-3209,3306
Year: 2015 Issue: 29
Journal: Modern Journal of Integrated Traditional Chinese and Western Medicine
Keyword: Fuyuanxingnao Decoction; lacunar infarction; interleukin-6; tumor necrosis factor -α; nitric oxide;
Abstract: Objective It is to observe the effect of Fuyuanxingnao Decoction combined with western medicine in patients with lacunar infarction and their impact on the levels of interleukin -6 ( IL-6) , tumor necrosis factor -α( TNF-α) and nitric oxide ( NO ) .Methods 90 patients with lacunar infarction were randomly divided into observation group and control group, each group had 45 cases.Control group received conventional drug treatment, observation group were treated with Fuyuanxingnao Decoction in the basis of the control group.Efficacy after treatment were observed in each group, the US Na-tional Institutes of Health neurological deficits ( NIHSS) , Barthel Index Rating Scale ( BI) score, carotid intima-media thick-ness (IMT), IL-6, TNF-αand NO levels were also detected before and after treatment in both groups.Results The total effective rate in observation group was significantly higher than that in control group (P<0.05).After treatment the levels of NIHSS, IMT, IL-6, TNF-αand NO were significantly lower, while the levels of BI was significantly higher than those be-fore treatment in both groups(P<0.05), the changes were more obvious in observation group (P<0.05).Conclusion Fuyuanxingnao Decoction combined with western medicine had a good effect on lacunar infarction, it can reduce neurological damage and improve function in daily life, its mechanism may be related to inhibit the body's release of inflammatory media-tors.
Pages: 3207-3209,3306
Year: 2015 Issue: 29
Journal: Modern Journal of Integrated Traditional Chinese and Western Medicine
Keyword: Fuyuanxingnao Decoction; lacunar infarction; interleukin-6; tumor necrosis factor -α; nitric oxide;
Abstract: Objective It is to observe the effect of Fuyuanxingnao Decoction combined with western medicine in patients with lacunar infarction and their impact on the levels of interleukin -6 ( IL-6) , tumor necrosis factor -α( TNF-α) and nitric oxide ( NO ) .Methods 90 patients with lacunar infarction were randomly divided into observation group and control group, each group had 45 cases.Control group received conventional drug treatment, observation group were treated with Fuyuanxingnao Decoction in the basis of the control group.Efficacy after treatment were observed in each group, the US Na-tional Institutes of Health neurological deficits ( NIHSS) , Barthel Index Rating Scale ( BI) score, carotid intima-media thick-ness (IMT), IL-6, TNF-αand NO levels were also detected before and after treatment in both groups.Results The total effective rate in observation group was significantly higher than that in control group (P<0.05).After treatment the levels of NIHSS, IMT, IL-6, TNF-αand NO were significantly lower, while the levels of BI was significantly higher than those be-fore treatment in both groups(P<0.05), the changes were more obvious in observation group (P<0.05).Conclusion Fuyuanxingnao Decoction combined with western medicine had a good effect on lacunar infarction, it can reduce neurological damage and improve function in daily life, its mechanism may be related to inhibit the body's release of inflammatory media-tors.
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