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Association of C-reactive protein gene +1444 C/T polymorphism with endometrial cancer
Author(s): Wang Li-juan, Bayinjili, Lu Huaiwu, Li Jing, Lin Zhongqiu
Pages: 515-
519
Year: 2015
Issue:
8
Journal: New Chinese Medicine
Keyword: C-reactive protein; Gene polymorphism; Endometrial cancer;
Abstract: Objective To investigate the potential association between C-reactive protein (CRP) gene +1 444 C /T polymorphism and endometrial cancer.Methods In this study,203 patients with endome-trial cancer (EC)and 203 healthy controls were enrolled into the EC and control groups.The CRP gene +1 444 C /T polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).The serum hsCRP levels combined with alternative clinical data were determined for subsequent analysis.Results The serum hsCRP level in the EC group was significantly higher compared with that in the control group (P <0.05).No statistical significance was documented in the frequencies of CC,CT and TT genotypes between two groups (P >0.05).Compared with EC patients with normal BMI (<25 kg/m2 ),a significantly higher frequency of CC genotype and C allele type was found in those with BMI≥25 kg/m2 (P <0.05).In addition,women with CC genotype or C allele type had significantly higher serum hsCRP levels com-pared with those with CT and TT genotypes or T allele type (both P <0.05).Conclusion CRP gene +1 444 C /T polymorphism,insulin resistance and inflammatory factors may collectively affect the risk of EC.
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