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The efficacy of glucocorticosteroid on the treatment of severe or refractory mycoplasma pneumoniae ;pneumonia
Author(s): 
Pages: 535-538
Year: Issue:  8
Journal: New Chinese Medicine

Keyword:  Mycoplasma pneumoniaeSevere symdromeGlucocorticoidChildren;
Abstract: Objective To investigate the effect of glucocorticoid on the treatment of severe and re-fractory mycoplasma pneumoniae (MP)pneumonia in children.Methods Thirty seven patients (aged 2 months ~1 4 years,median 36 months)with severe or refractory MP pneumonia were divided into the two groups:treatment group (n =22)and control group (n =1 5).The patients in the two groups were treated with routine oral or intravenous azithromycin,and received the combined therapy including oxygen inhalation,atom-ization inhalation,and postural drainage.The patients in the treatment group were additionally treated with in-travenous methylprednisolone (daily,2 ~3 mg/kg)for 3 ~5 days,and then with prednisone (daily,1 ~2 mg/kg)orally and gradually reduced,maintained 7 ~1 0 days.Differences of clinical symptoms,and hospitali-zation time were compared between the two groups.Results The symptom of all the children were significantly improved,the patients’condition was significantly improved and discharged.The hospitalization time of the patients in the treatment group was decreased compared with that of the patients in the control group (8.45 ± 3.1 4 vs.1 1 .07 ±2.74,P <0.05).The total duration of fever of the patients in the treatment group was shor-ter compared with that of the patients in the control group (4.52 ±2.77 vs.6.80 ±3.76,P <0.05).The cough improve time of the patients in the treatment group was decreased compared with that of the patients in the control group (3.48 ±1 .37 vs.4.53 ±1 .49,P <0.05).Conclusions The use of suitable dosage and short treatment period of corticosteroids contributes to reduce the therapy time of severe or refractory MP pneu-monia in children.
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