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Clinical value of application of Cervista high-risk HPV genotyping in screening of cervical cancer
Author(s): Chen Xinmei, Wang Chuhua, Liu Luhui, Wang Luanling, Xiao Xingkui, Guo Xiaoqin
Pages: 555-
559
Year: 2015
Issue:
8
Journal: New Chinese Medicine
Keyword: Cervista high-risk HPV testing; Cervical cancer; Cervical intraepithelial neoplasia; Liquid-based cytology test;
Abstract: Objective To observe the validity and clinical value of the Cervista high-risk human pap-illomaviral infection (HR-HPV)testing and HPV genotyping in the screening of cervical cancer.Methods A total of 1 000 women simultaneously received liquid-based cytology (TCT)and Cervista technology for detection of HR-HPV.Patitents suspected with cytological characteristics of atypicai squamous cells of unknown signifi-cance (ASC-US)grade or above underwent histopathological biopsy.Cytological and pathological grades were evaluated.HR-HPV genotypes (A9,A7 and A5 /A6)of different TCT and pathological grades were recorded.The relationship between HR-HPV genotype and CINⅢ grade or above was analyzed.Results The positive rate of HR-HPV in subjects with ASCUS grade or above was significantly higher compared with those of normal and inflammatory counterparts.Compared with ASC-US subjects,those with LSIL and HSIL grade had a signif-icantly higher positive rate of HR-HPV.The positive rate of HR-HPV in those with HSIL grade was considera-bly higher than that of the subjects with ASC-H grade (all P <0.005).The positive rate of type A9 HPV in-fection in the subjects with LSIL and HSIL grade was significantly higher than that in normal and inflammation counterparts.The positive rate of type A9 HPV infection in the HSIL subjects was apparently higher than that in the ASC-US counterparts (both P <0.005).Cytological testing revealed that 246 subjects developed ASC-US grade or above and subsequently received pathological biopsy.The positive rate of HR-HPV was gradually increased from 40.9% during the inflammation stage to 92.9% in the CINⅢ stage.The subjects with CINⅡand CINⅢ grade had significantly higher positive rates of type A9 HR-HPV compared with their counterparts with inflammation and CIN I (all P <0.005).For CINⅢ grade or above,the sensitivity,specificity,positive and negative predictive values of Cervista HR-HPV were 93.8%,48.8%,6.7% and 99.0%,respectively.Youden's index was 0.42.Among different HR-HPV genotypes,the sensitivity and Youden's index of A9 type HR-HPV were the highest.Conclusion Cervista HR-HPV has a high sensitivity and negative predictive value in the screening of CIN III grade or above HR-HPV,which can be applied in the screening of cervical cancer.If detected with type A9 HR-HPV infection,the patients should receive further examination and should be closely followed up.
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