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The expression levels of serum IL-37 and IL-18, and their clinical significances in patients with atopic dermatitis
Pages: 271-273
Year: Issue:  5
Journal: Journal of Clinical Dermatology

Keyword:  atopic dermatitisIL-18IL-37;
Abstract: Objective: To assess the levels of serum interleukin(IL)-18 and IL-37 in the patients with atopic dermatitis(AD) and their clinical relevance. Methods: The serum concentrations of IL-18 and IL-37 were measured by ELISA in 45 AD patients and 30 normal controls. The correlation between these cytokine levels and disease severity were analyzed. Results: Compared with normal controls, both IL-18 and IL-37 levels increased significantly in AD patients, and were positively correlated with SCORAD. Additionally, the levels of IL-18 were also positively correlated with the levels of IL-37. The levels of serum IL-18 were not significant different among mild, moderate and severe AD, while the differences of IL-37 levels were significant between mild and severe AD. Conclusion: IL-18 and IL-37 may be crucial indicators for the progression of AD. IL-18 and IL-37 both together play a role in AD.
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