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Secondary myelodysplastic syndrome induced by chronic lead poisoning:one case report
Author(s): Li Guodong, Cheng Zhiyong, Wang Fengyun, Xie Xulei, Zhang Aihong, Xie Na
Pages: 414-
416
Year: 2015
Issue:
6
Journal: New Chinese Medicine
Keyword: Lead poisoning; chronic; Myelodysplastic syndromes; Secondary;
Abstract: Myelodysplastic syndrome (MDS)is malignant cloning disease of multipotential stem cells characterized by ineffective hematopoiesis of the bone marrow,peripheral single-or multi-lineage pancytopenia and single-or multi-lineage dyaplasia,and has a risk of evolving into acute leukemia.MDS can be divided into primary and secondary categories.It has been proven that lead poisoning can result in hematopoietic system dis-orders.In this paper,we reported one patient developing secondary MDS (s-MDS)after long-term exposure to lead.The patient presented with significantly elevated levels of lead in the blood and urine,pancytopenia and clonal chromosome abnormalities.After lead excretion,routine blood test revealed almost normal outcomes. The patient was physically stable during subsequent follow-up.Therefore,patients with lead poisoning and ab-normality of routine blood test should further receive bone marrow and chromosome examinations to exclude the possibility of s-MDS.
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