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Clinical efficacy of super-selective lingual arterial transcatheter chemoembolization in treating moderate and advanced tongue cancer
Author(s): Lu Xin, Zeng Guobin, Lin Longqian, Liao Li'an, Zou Meihua
Pages: 324-
327
Year: 2015
Issue:
5
Journal: New Chinese Medicine
Keyword: Tongue carcinoma; Arterial catheterization; Chemoembolization;
Abstract: Objective To investigate the value of super-selective lingual arterial transcatheter chemo-embolization in the treatment of moderate and advanced tongue carcinoma.Methods Eleven patients were di-agnosed with T2 ~T4 tongue squamous cell cancer according to TNM staging.All patients were injected with cisplatin 120 mg,boanmycin hydrochloride 50 mg and a slight amount of gelatin sponge particles via super-se-lective catheterization from the lingual artery to the right femoral artery.Radical resection was performed 3 ~4 weeks later.Radiotherapy at a dosage of DT 50 Gy was conducted following surgery.Results At 10 d after chemoembolization,the tumor size was reduced to varying extent.Postoperatively,3 cases had mild and moder-ate fever,four with mild nausea and one with slight vomiting.No bone marrow suppression,hepatic and renal function injuries or alternative systemic adverse events were noted.Tumor evaluation before radical resection re-vealed that two patients had complete remission and nine partial remission with an effective rate of 100%.All tumors were completely resected intraoperatively.Postoperative pathological examination demonstrated that ap-parent necrotic lesions were found in the tumor tissues.Neither tumor recurrence nor metastasis was found after 1-year follow-up.Conclusion Super-selective lingual arterial transcatheter chemoembolization was a safe and effective treatment of moderate and advanced tongue cancer,yielding few adverse events.
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