Author(s): JIANG Lu, HAN Nianhua
Pages: 87-89
Year: 2015 Issue:  2
Journal: Haerbin Medical Journal
Keyword:  Renal failure; Cognition; Insulin resistance;
Abstract: Objective To explore the relationship between cognitive impairment and insulin resistance in non-dialysis patients with chronic renal failure( CRF) . Methods A total of 72 patients with CRF were divided into two groups:cognitive impairment group and non-cognitive impairment group. The weight,body mass index(BMI),fasting serum glucose,insulin,total cholesterol(TC),tri-glyceride( TG) ,intima-media thickness( IMT) and CRP were detected. The difference of these indexes and HOMA-IR were com-pared between cognitive impairment group and non-cognitive impairment group. Results Compared with non-cognitive impairment group,the BMI,FPG,TG,CRP,IMT,CCr and HOMA-IR in cognitive impairment group increased markedly(P<0. 05),CCr was lower. The Logistic regression analysis showed that CCr, HOMA - IR, and CRP had an impact on the incidence of cognitive impairment . Conclusion HOMA-IR,CRP and CCr were the independent risk factors for developing cognitive impairment in pa-tients with chronic kidney disease.