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Raman Spectral Analysis of Rectum Cancer by Serum Using PCA-LDA and Parameter-CART Methods
Pages: 73-76
Year: Issue:  1
Journal: Acta Laser Biology Sinica

Keyword:  Raman spectroscopyserumrectum cancerdiagnosis;
Abstract: Raman spectroscopy technique was used in this paper to detect the changes of the components in serum ac-company with the occurrence of rectum cancer.The differences in Raman spectroscopy of serum between rectum cancer and the healthy controls were examined.Post-operative rectum cancer patients were also participated in the comparison to monitor the effects of the operation.The results showed that there are significant variations at certain wavenumbers which are predications of the alteration of corresponding biological substances.Then,principal component analysis (PCA)and parameters of intensity ratios were used on the original Raman spectra for the extraction of featured variables.Linear dis-criminant analysis (LDA)and classification and regression tree (CART)were used on the featured variables for the dis-crimination analysis.Accuracies of 87% and 90% were got for separate PCA-LDA and Parameter-CART.
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