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Research on the Confocal Raman micro-spectroscopic Characters of Inflammatory Labial Gland Tissues
Pages: 95-99
Year: Issue:  1
Journal: Acta Laser Biology Sinica

Keyword:  lip glandinflammatory lesionsRaman spectroscopydiagnosis;
Abstract: Objective:Research the Raman spectra of inflammatory labial gland tissues in order to provide a research-based theoretical foundation for applying Raman spectroscopy to diagnoses the inflammatory labial gland diseases.Meth-ods:30 samples of Sjogren’s syndrome labial glands,18 samples of acute inflammatory labial glands and 30 samples of normal labial glands were collected and scanned by confocal Raman micro-spectrometer.The methods of principal com-ponent analysis (PCA)and discrimination function analysis (DFA)were employed to analyze the spectral data and dis-criminate the different tissues.Results:Differences were discovered between in the Raman spectra of various labial gland tissues,which were assigned to biomolecules such as proteins,nucleic acids and lipids.The accuracy of discrimination carried out by PCA-DFA reached 91.8% and the accuracy of cross-validaiton was 89.4%.Conclusion:The differences existing in Raman spectra of labial glands could not only reflect the biomolecular alterations but also diagnose the labial gland diseases.Raman spectroscopy had the potential to be utilized in the clinical diagnosis.
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