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Expression of CD55 and CD59 in chronic rhinosinusitis and its significance
Pages: 1021-1023
Year: Issue:  12
Journal: Chinese Journal of Otorhinolaryngology Head and Neck Surgery

Keyword:  AntigenCD55AntigenCD59Flow cytometrySinusitis;
Abstract: Objective To understand the expression of complement regulatory proteins CD55 and CD59,which secreted by epithelial cells of normal and chronic sinusitis patients.Methods Cell culture and flow cytometry were used to detect the expression of complement regulatory proteins CD55 and CD59.SPSS 18.0 software was used to analyze the data.Results CD55 was expressed both in normal nasal mucosa and mucosa of chronic sinusitis.The expression in normal group was 0.001 ±0.001,significantly lower than that in CRS group which was 0.067 ± 0.028 (t =-10.535,P < 0.01).CD59 was also expressed in the two groups.In normal group,the expression of CD59 was 0.879 ± 0.005,significantly higher than that in CRS group which was 0.238 ± 0.034 (t =83.416,P <0.01).Conclusions The nasal mucosa in CRS patients showed low expression of CD55 and high expression of CD59.This mechanism may be involved in the occurrence of CRS.
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