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Influence of betahistine on the expression of histamine H3 receptor in the medial vestibular nucleus following unilateral labyrinthectomy in guinea pigs
Author(s): 
Pages: 1027-1030
Year: Issue:  12
Journal: Chinese Journal of Otorhinolaryngology Head and Neck Surgery

Keyword:  BetahistineGuinea pigsReceptorshistamine H3Vestibular nuclei;
Abstract: Objective To observe the influence of betahistine on the expression of histamine H3 receptor in the medial vestibular nucleus (MVN) following unilateral labyrinthectomy (UL).Methods Fifty-six healthy guinea pigs were randomly divided into three groups:the sham-operated group (group Ⅰ),the UL group [group Ⅱ,and UL + betahistine (BET) group (group Ⅲ)],BET was intraperitoneally injection at 2.17 mg · kg-1 · d-1 for 7 days.The expression of histamine H3 receptor was analyzed by immunohistochemistry at 1 day,3 days and 7 days after UL.Results H3 receptors were presented in the MVN and the expression of histamine H3 receptor were increased significantly in the ipsilateral MVN at 1 and 3 days after UL(P <0.05),the change turned into the normal value at 7 days(P >0.05).In the UL + BET group,the intensity of histamine H3 receptor was lower than that in the UL at 1 day and 3 days(4.25 ± 0.71,3.50 ± 0.92 vs 5.75 ± 0.71,5.50 ± 0.93,P < 0.05).However,the changes turned into the normal values at 3 and 7 days (P > 0.05).Conclusions The early stage of the vestibular compensation process may be associated with the change of H3 receptor expression in MVN.In the UL + BET group the histamine H3 receptor recovered quickly.
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