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The expression and clinical relevance between STAT3 and TGF-β1 from peripheral blood in patients with SLE
Author(s): 
Pages: 586-589
Year: Issue:  10
Journal: Journal of Clinical Dermatology

Keyword:  lupus erythematosussystemicSTAT3TGF-β1;
Abstract: 目的:探讨信号转导和转录激活因子3(signal transducer and activator of transcription 3,STAT3)和转化生长因子(transforming growth factor,TGF)β1在系统性红斑狼疮(systemic lupus erythematosus,SLE)患者与正常人外周血单一核细胞(PBMC)中的表达差异及其与临床和实验室指标的相关性;探讨STAT3和TGF-β1在SLE发病机制中的调节作用.方法:收集40例SLE患者和40例正常人对照的外周血标本,采用反转录-聚合酶链反应(RT-PCR)方法检测其PBMC中STAT3和TGF-β1表达水平;利用SPSS16.0分析STAT3和TGF-β1的表达及其与临床特征的相关性.结果:SLE患者PBMC中STAT3和TGF-β1的表达水平明显高于正常人对照组[STAT3 mRNA的△CT值分别为2.34±0.38和3.03±0.48(t=7.09,P<0.01);TGF-β1 mRNA的△CT值分别为3.54±0.71和4.27±0.81 (t=4.30,P<0.01)],且与SLE活动性指数(SLEDAI)呈正相关(r值分别为-0.32和-0.37,P均<0.05);活动期的SLE患者STAT3和TGF-β1的mRNA表达量明显高于静止期患者[STAT3 mRNA的△CT值分别为2.21±0.38和2.53±0.30 (t=2.93,P<0.01);TGF-β1 mRNA的△CT值分别为3.29±0.57和3.81±0.76 (t=2.46,P<0.05)];伴有发热的SLE患者STAT3的mRNA表达量明显高于无发热的患者[STAT3 mRNA的△CT值分别为2.11±0.47和2.40±0.33(t=2.09,P<0.05)].结论:STAT3和TGF-β1可能参与了SLE的发病过程;STAT3和TGF-β1与SLE病情活动性有关;STAT3可能参与了发热的过程.
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