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Experiences with application of levosimendan in cardiac surgical patients during early postoperative stage
Author(s): 
Pages: 758-762
Year: Issue:  11
Journal: New Chinese Medicine

Keyword:  LevosimendanCardiac surgeryAcute cardiac dysfunctionPostoperative;
Abstract: Objective To explore the application significance of levosimendan in early stage after the open heart surgery in critical patients. Methods Eighty-eight critical patients who presented with acute cardi-ac dysfunction after cardiac surgery and were treated with levosimendan. The changes in dosage of vasoactive drugs,hemodynamics,proBNP and LVEF were analyzed before and after use of levosimendan. Results The doses of dopamine and norepinephrine at 8 h after use of levosimendan were lower than those before levosimen-dan(P<0.05 ). The dosages of dopamine and norepinephrine at 24 h later were significantly higher compared with those prior to use of levosimendan (P<0.05 ). At 8 h after use of levosimendan,the doses of dobutamine and adrenaline began to decrease and even remain unchanged,significantly differing from the levels before use of levosimendan. The systolic blood pressure(SBP)and heart rate(HR)did not significantly change,whereas central venous pressure(CVP)and lactic acid (Lac)had a declining trend. CVP significantly changed at 24 h after use of levosimendan(P<0.05 ). Lac significantly differed at 24 h following use of levosimendan. Urine volume began to significantly increase at 8 h after use of levosimendan(P<0.05 ). The levels of LVEF were significantly elevated at 24 h,3 d and 1 week after using levosimendan(all P<0.01 ). The level of proBNP gradually declined and significantly differed at 3 d after use of levosimendan (P<0.05 ). Conclusions Ap-plication of evosimendan after open heart surgery can reduce the dosage of vasoactive drugs,maintain the stabil-ity of hemodynamics and effectively improve heart function in critical patients.
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