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Relationship between psoriatic arthritis and C-terminal cross-linking telopeptide of type Ⅰ collagen
Author(s): 
Pages: 327-329
Year: Issue:  6
Journal: Journal of Clinical Dermatology

Keyword:  psoriasis arthropathicapyridinoline cross-linked carboxy-terminal telopeptide of type Ⅰ collagenrelationship;
Abstract: 目的:通过分析关节病性银屑病(PSA)患者治疗前后血清中Ⅰ型胶原吡啶交联终肽(ICTP)的变化,探讨ICTP检测在PSA诊断、治疗中的作用.方法:收集来自西安市第五医院及西北工业大学医院2008年5月-2012年10月门诊及住院确诊的PSA患者21例,并给予药物联合治疗,于第0、6个月分别留取患者血清并与寻常性银屑病52例、类风湿关节炎(RA)患者80例和健康人群88例作对比分析.应用ELISA法测定患者血清中ICTP水平和血沉(ESR).结果:ICTP在PSA和RA患者中显著升高(P<0.01);治疗后PSA患者血清中的ICTP浓度明显下降(P<0.01).结论:PSA患者血清中ICTP浓度明显升高并且随着治疗后病情的好转而降低,提示检测血清ICTP的变化对PSA患者的诊断及疗效判断有一定的临床意义.
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