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Changes in epidermal permeability barrier function in atopic dermatitis and its clinical implication
Author(s): 
Pages: 671-673
Year: Issue:  10
Journal: JOURNAL OF CLINICAL DERMATOLOGY

Keyword:  皮炎特应性屏障功能皮肤含水量角质层pH值;
Abstract: 皮肤的生理指标包括皮肤的水通透屏障功能、角质层的水分含量以及皮肤表面的pH值等,这些生理指标反映了机体和皮肤局部的生理状态.除角质层的水分含量降低以及皮肤表面的pH值升高外,特应性皮炎(AD)患者皮肤屏障功能明显降低.这一变化是AD表皮病变所致,其可影响表皮和真皮的功能.皮肤生理的改变程度与病情有关,通过改善皮肤屏障功能可以缓解AD病情.因此,正确地了解AD患者皮肤屏障功能的改变对于病情的判断和疾病的防治有一定的临床指导意义.
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