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Study of Differential Gene Expression Profiling in Peripheral Blood Lymphocyte of Rat with 2 .0 Gy Gamma Ray Irradiation
Pages: 1-7
Year: Issue:  4
Journal: Radiation Protection Bulletin

Keyword:  RatLymphocyteGene chipDifferential expression geneGamma-ray;
Abstract: The study analyzed the differential expression profile and pathway of peripheral blood lymphocyte in SD rats 6 ,12 and 24 hours after irradiation to 2 .0 Gy gamma ray .The results showed that at 6 hours after ir-radiation there were 1084 differentially expressed genes of which 736 genes were up-regulated and 348 genes down-regulated .12 hours after irradiation there were 2590 differentially expressed genes of which 1621 genes were up-regulated and 969 genes down-regulated .24 hours after irradiation there were 3938 differentially ex-pressed genes of which 2278 genes were up-regulated and 1660 genes down-regulated .There were 446 co-ex-pressed differential genes at three time points ,of which 274 genes were up-regulated and 172 genes down-regu-lated .The KEGG analysis revealed that 6h point 18 pathways ,12 hours point 35 pathways ,and 24 hours point 38 pathways involved .RT-PCR results indicated that the relative quantity’s results of Trmt61a and Enc1 were consistent with gene chip data .
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