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Study on IGF-1R Gene Expression in Blood Cells and Liver Tissues of Mice Irradiated with gamma Rays
Author(s): 
Pages: 13-19
Year: Issue:  4
Journal: Radiation Protection Bulletin

Keyword:  MouseIGF-1RReal-time fluorescent quantitative PCRGamma-ray;
Abstract: This study is to investigate the irradiation effect at different does and different time on the expres-sion of insulin like growth factor type 1 receptor type 1 (IGF-1R) in mice .The mice were irradiated with 60 Co gamma rays at 1 .0 ,2 .0 and 4 .0 Gy ,then extracted total RNA from blood cells and liver tissues after irradi-ation 6 ,12 and 24 hours .IGF-1R expression in blood cells and liver tissues were detected by real-time fluo-rescent quantitative PCR .Solution curve ofβ-actin gene and (IGF-1R) with different doses and time was the single peak ,which means the specific ampliations . IGF-1R gene expression in blood cells and liver tissues showed down regulation ,The 4 .0 Gy 24 hours group expressed the lowest level in blood cells .The 4 .0 Gy 6 hours group expressed the lowest level in liver tissues .
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