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Expression of peripheral blood γδ T cells, Treg cells and cytokines IL-17 and TGF-β1 in patients with allergic rhinitis
Author(s): 
Pages: 544-548
Year: Issue:  7
Journal: Chinese Journal of Otorhinolaryngology Head and Neck Surgery

Keyword:  ReceptorsantigenT-cellgamma-deltaT-lymphocytesregulatoryInterleukin-17Transforming growth factor beta 1RhinitisallergicperennialRhinitisallergicseasonal;
Abstract: Objective To investigate the expression of peripheral blood γδ T cells/CD4 + CD25 + regulatory T cells(Treg) and cytokines interleukin 17 (IL-17) and transforming growth factor β1 (TGF-β1) in patients with allergic rhinitis.Methods From March 2012 to July 2012,32 patients with allergic rhinitis (AR group) and 20 healthy control subjects (control group) were collected.The expression of peripheral blood γδ T cells/Treg cells were measured by flow cytometry and the levels of IL-17 and TGF-β1 were evaluated by ELISA.SPSS 16.0 software was used to analyze the data.Results The percentages of γδT cells in AR group were (13.30 ±8.62)%,which was significantly higher (t =5.18,P <0.01) than those in control group (5.18 ± 1.86)%.The percentages of Treg cells in AR group were (1.75 ±0.56)%,which were significantly lower (t =7.46,P < 0.01) than those in control group (4.76 ± 1.74) %.The IL-17 levels in AR group were (668.55 ±45.15) pg/ml,which were also significantly higher (t =8.97,P < 0.01) than those in control group (573.53 ± 17.42) pg/ml.The TGF-β1 levels in AR group were (0.34 ±0.04) pg/ml,which were also significantly lower (t =9.51,P <0.01) than those in control group(0.49 ± 0.06) pg/ml.There was a negative correlation between the percentages of γδ T cells and Treg cells (r =-0.561,P <0.01).There was a negative correlation between the percentages of γδ T cells and TGF-β1 levels (r =-0.622,P < 0.01).A positive correlation was shown between the percentages of βδ T cells and IL-17 levels in AR (r =0.469,P < 0.01).A positive correlation was shown between the percentages of Treg cells and TGF-β1 levels in AR (r =0.738,P <0.01).There was no correlation between IL-17 levels and the percentages of Treg cells or TGF-β1 levels (r value was-0.111,-0.196,all P > 0.05).Conclusion There are imbalances of γδ T and Treg cells in peripheral blood of patients with allergic rhinitis.γδ T cells may be the main cell to produce IL-17,which may play an important role in allergic rhinitis.
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