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Author:
Journal / Book Title:
Year:
Volume:
Issue:
diao zheng xue ya de ji yin
Author(s):
LIN Zhi
Pages:
24
Year:
1989
Issue:
5
Journal:
Journal of Medical Research
Keyword:
原发高血压
;
血管紧张肽原酶
;
基因片段
;
过敏
;
大白鼠
;
人类遗传
;
等位基因
;
大鼠
;
基因位点
;
酶基因
;
Abstract:
<正> Everal基因位点似乎对原发高血压有一定作用。用作人类遗传病模式的盐过敏Dahl大白鼠中,一般认为有2-4个位点决定血压。位点之一是血管紧张肽原酶(re-nin),已由Rapp等鉴定,并描述其特征。用限制酶切碎血管紧张肽原酶基因,可观察到纯合子型“盐过敏”和“抗盐”的Dahl大鼠中,基因片段长度和结构有差异。“盐过敏”鼠和“抗盐”大鼠杂交后产生的第
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