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Prevention of Arterial Intimal Hyperplasia after Injury by Photodynamic Therapy
Author(s): 
Pages: 120-123
Year: Issue:  2
Journal: ACTA LASER BIOLOGY SINICA

Keyword:  光动力疗法血啉甲醚血管成形术后再狭窄;
Abstract: Objective:To investigate the rationality a nd validity of photodynamic therapy(PDT) in the prevention of arterial intimal h yperplasia after acute injury.Results:Ratios of the media/in tima for groups 1,2,3,and 4 were 4.6±1.2,3.3±0.8,2.1±0.3,and 2.4±0.5,resp ectively. The ratio of groups 1 was significantly increased when compared with group 2,3 and group 4(P<0.01).Ratio s of the intima/media were significantly reduced in group 3 and 4 when compared with group 1 and group 2(P<0.01).Conclusion:The best parame ters of PDT with HMME as the photosensitizer is :irradiated with 30?mW/cm2 fo r 15?min,and HMME of 5?mg/kg,and PDT was effective in reducing intimal hyperpl asia following arterial injury with the selected parameters.
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