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tian zuo chuang huan zhe xue qing zhong ju shi xi bao you zou yi zhi yin zi de jian ce ji lin chuang yi yi
Author(s): 
Pages: 18-19
Year: Issue:  1
Journal: Journal of Clinical Dermatology

Keyword:  天疱疮;
Abstract: 巨噬细胞游走抑制因子(macrophage migration inhibitory factor,MIF)是最早被识别的细胞因子之一.越来越多的研究表明,MIF涉及败血症、炎症和自身免疫性疾病以及肿瘤的发病机制.近年来,已有MIF与系统性红斑狼疮[1]、系统性硬皮病[2]、特应性皮炎[3]、银屑病[4]等多种皮肤疾病的相关研究报道.但是,针对病情较重、顽固难治的大疱性疾病的MIF相关研究很少.本实验旨在通过分别检测天疱疮患者、大疱性类天疱疮(BP)患者和正常人群的血清MIF浓度,探讨MIF在天疱疮发病机制中的临床意义,以及不同亚型、不同病情严重程度天疱疮患者血清MIF的差异性,并为天疱疮发病机制的探讨提供线索.
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